Device thrombogenicity emulation: a novel method for optimizing mechanical circulatory support device thromboresistance.

ABSTRACT: Mechanical circulatory support (MCS) devices provide both short and long term hemodynamic support for advanced heart failure patients. Unfortunately these devices remain plagued by thromboembolic complications associated with chronic platelet activation--mandating complex, lifelong anticoagulation therapy. To address the unmet need for enhancing the thromboresistance of these devices to extend their long term use, we developed a universal predictive methodology entitled Device Thrombogenicity Emulation (DTE) that facilitates optimizing the thrombogenic performance of any MCS device--ideally to a level that may obviate the need for mandatory anticoagulation. DTE combines in silico numerical simulations with in vitro measurements by correlating device hemodynamics with platelet activity coag

SUBMITTER: Girdhar G 

PROVIDER: S-EPMC3292570 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature