Direct comparison of different stem cell types and subpopulations reveals superior paracrine potency and myocardial repair efficacy with cardiosphere-derived cells.

ABSTRACT:

Objectives

The goal of this study was to conduct a direct head-to-head comparison of different stem cell types in vitro for various assays of potency and in vivo for functional myocardial repair in the same mouse model of myocardial infarction.

Background

Adult stem cells of diverse origins (e.g., bone marrow, fat, heart) and antigenic identity have been studied for repair of the damaged heart, but the relative utility of the various cell types remains unclear.

Methods

Human cardiosphere-derived cells (CDCs), bone marrow-derived mesenchymal stem cells, adipose tissue-derived mesenchymal stem cells, and bone marrow mononuclear cells were compared.

Results

CDCs revealed a distinctive phenotype with uniform expression of CD105, partial expression of c-kit and CD90

SUBMITTER: Li TS 

PROVIDER: S-EPMC3292778 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature