Catenin-dependent cadherin function drives divisional segregation of spinal motor neurons.

ABSTRACT: Motor neurons that control limb movements are organized as a neuronal nucleus in the developing ventral horn of the spinal cord called the lateral motor column. Neuronal migration segregates motor neurons into distinct lateral and medial divisions within the lateral motor column that project axons to dorsal or ventral limb targets, respectively. This migratory phase is followed by an aggregation phase whereby motor neurons within a division that project to the same muscle cluster together. These later phases of motor neuron organization depend on limb-regulated differential cadherin expression within motor neurons. Initially, all motor neurons display the same cadherin expression profile, which coincides with the migratory phase of motor neuron segregation. Here, we show that this early, p

SUBMITTER: Bello SM 

PROVIDER: S-EPMC3292792 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature