Molecular complexity via C-H activation: a dehydrogenative Diels-Alder reaction.

ABSTRACT: Traditionally, C-H oxidation reactions install oxidized functionality onto a preformed molecular skeleton, resulting in a local molecular change. The use of C-H activation chemistry to construct complex molecular scaffolds is a new area with tremendous potential in synthesis. We report a Pd(II)/bis-sulfoxide-catalyzed dehydrogenative Diels-Alder reaction that converts simple terminal olefins into complex cycloadducts in a single operation.

SUBMITTER: Stang EM 

PROVIDER: S-EPMC3292869 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature