Computational analysis of pathogen-borne metallo β-lactamases reveals discriminating structural features between B1 types.

ABSTRACT:

Background

Genes conferring antibiotic resistance to groups of bacterial pathogens are cause for considerable concern, as many once-reliable antibiotics continue to see a reduction in efficacy. The recent discovery of the metallo β-lactamase blaNDM-1 gene, which appears to grant antibiotic resistance to a variety of Enterobacteriaceae via a mobile plasmid, is one example of this distressing trend. The following work describes a computational analysis of pathogen-borne MBLs that focuses on the structural aspects of characterized proteins.

Results

Using both sequence and structural analyses, we examine residues and structural features specific to various pathogen-borne MBL types. This analysis identifies a linker region within MBL-like folds that may act as a discriminating st

SUBMITTER: Cadag E 

PROVIDER: S-EPMC3293060 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature