Comparison of screening strategies to improve the diagnosis of latent tuberculosis infection in the HIV-positive population: a cohort study.

ABSTRACT:

Background

HIV is the most important risk factor for progression of latent tuberculosis infection (LTBI) to active tuberculosis (TB). Detection and treatment of LTBI is necessary to reduce the increasing burden of TB in the UK, but a unified LTBI screening approach has not been adopted.

Objective

To compare the effectiveness of a TB risk-focused approach to LTBI screening in the HIV-positive population against current UK National Institute for Health and Clinical Excellence (NICE) guidance.

Design

Prospective cohort study.

Setting

Two urban HIV treatment centres in London, UK.

Participants

114 HIV-infected individuals with defined TB risk factors were enrolled prospectively as part of ongoing studies into HIV and TB co-infection.

Outcome measures

SUBMITTER: Pollock KM 

PROVIDER: S-EPMC3293130 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature