Effect of acute intraocular pressure elevation on the monkey optic nerve head as detected by spectral domain optical coherence tomography.

ABSTRACT:

Purpose

To determine whether acutely elevated IOP alters optic nerve head (ONH) structural parameters characterized in vivo using spectral domain optical coherence tomography (SD-OCT).

Methods

Five rhesus macaques were tested under isoflurane anesthesia. SD-OCT images of the ONH of both eyes were acquired 30 minutes after IOP was stabilized to 10 mm Hg and 60 minutes after stabilization to 45 mm Hg. The internal limiting membrane, Bruch's membrane/retinal pigment epithelium, neural canal opening (NCO), and anterior lamina cribrosa surface (ALCS) were delineated using custom software. Differences in SD-OCT structural parameters between the two IOP levels were assessed using generalized estimating equations. In six eyes of three animals, images were acquired after 10 minutes a

SUBMITTER: Strouthidis NG 

PROVIDER: S-EPMC3293414 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature