Selection of a phylogenetically informative region of the norovirus genome for outbreak linkage.

ABSTRACT: The recognition of a common source norovirus outbreak is supported by finding identical norovirus sequences in patients. Norovirus sequencing has been established in many (national) public health laboratories and academic centers, but often partial and different genome sequences are used. Therefore, agreement on a target sequence of sufficient diversity to resolve links between outbreaks is crucial. Although harmonization of laboratory methods is one of the keystone activities of networks that have the aim to identify common source norovirus outbreaks, this has proven difficult to accomplish, particularly in the international context. Here, we aimed at providing a method enabling identification of the genomic region informative of a common source norovirus outbreak by bio-informatic tools.

SUBMITTER: Verhoef L 

PROVIDER: S-EPMC3293504 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature