A transcriptional-switch model for Slr1738-controlled gene expression in the cyanobacterium Synechocystis.

ABSTRACT:

Background

Protein-DNA interactions play a crucial role in the life of biological organisms in controlling transcription, regulation, as well as DNA recombination and repair. The deep understanding of these processes, which requires the atomic description of the interactions occurring between the proteins and their DNA partners is often limited by the absence of a 3D structure of such complexes.

Results

In this study, using a method combining sequence homology, structural analogy modeling and biochemical data, we first build the 3D structure of the complex between the poorly-characterized PerR-like regulator Slr1738 and its target DNA, which controls the defences against metal and oxidative stresses in Synechocystis. In a second step, we propose an expanded version of the Sl

SUBMITTER: Garcin P 

PROVIDER: S-EPMC3293774 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature