The bone-forming effects of HIF-1α-transduced BMSCs promote osseointegration with dental implant in canine mandible.

ABSTRACT: The presence of insufficient bone volume remains a major clinical problem for dental implant placement to restore the oral function. Gene-transduced stem cells provide a promising approach for inducing bone regeneration and enhancing osseointegration in dental implants with tissue engineering technology. Our previous studies have demonstrated that the hypoxia-inducible factor-1α (HIF-1α) promotes osteogenesis in rat bone mesenchymal stem cells (BMSCs). In this study, the function of HIF-1α was validated for the first time in a preclinical large animal canine model in term of its ability to promote new bone formation in defects around implants as well as the osseointegration between tissue-engineered bone and dental implants. A lentiviral vector was constructed with the constitutively activ

SUBMITTER: Zou D 

PROVIDER: S-EPMC3293808 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature