A genome-wide association study identifies rs2000999 as a strong genetic determinant of circulating haptoglobin levels.

ABSTRACT: Haptoglobin is an acute phase inflammatory marker. Its main function is to bind hemoglobin released from erythrocytes to aid its elimination, and thereby haptoglobin prevents the generation of reactive oxygen species in the blood. Haptoglobin levels have been repeatedly associated with a variety of inflammation-linked infectious and non-infectious diseases, including malaria, tuberculosis, human immunodeficiency virus, hepatitis C, diabetes, carotid atherosclerosis, and acute myocardial infarction. However, a comprehensive genetic assessment of the inter-individual variability of circulating haptoglobin levels has not been conducted so far.We used a genome-wide association study initially conducted in 631 French children followed by a replication in three additional European sample sets an

SUBMITTER: Froguel P 

PROVIDER: S-EPMC3293812 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature