Multiscale feature analysis of salivary gland branching morphogenesis.

ABSTRACT: Pattern formation in developing tissues involves dynamic spatio-temporal changes in cellular organization and subsequent evolution of functional adult structures. Branching morphogenesis is a developmental mechanism by which patterns are generated in many developing organs, which is controlled by underlying molecular pathways. Understanding the relationship between molecular signaling, cellular behavior and resulting morphological change requires quantification and categorization of the cellular behavior. In this study, tissue-level and cellular changes in developing salivary gland in response to disruption of ROCK-mediated signaling by are modeled by building cell-graphs to compute mathematical features capturing structural properties at multiple scales. These features were used to genera

SUBMITTER: Bilgin CC 

PROVIDER: S-EPMC3293912 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature