A comprehensive analysis of Delta signaling in pre-gastrular sea urchin embryos.

ABSTRACT: In sea urchin embryos Delta signaling specifies non-skeletogenic mesoderm (NSM). Despite the identification of some direct targets, several aspects of Delta Notch (D/N) signaling remain supported only by circumstantial evidence. To obtain a detailed and more complete image of Delta function we followed a systems biology approach and evaluated the effects of D/N perturbation on expression levels of 205 genes up to gastrulation. This gene set includes virtually all transcription factors that are expressed in a localized fashion by mid-gastrulation, and which thus provide spatial regulatory information to the embryo. Also included are signaling factors and some pigment cell differentiation genes. We show that the number of pregastrular D/N signaling targets among these regulatory genes is sma

SUBMITTER: Materna SC 

PROVIDER: S-EPMC3294105 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature