The cytoplasmic tyrosine kinase Arg regulates gastrulation via control of actin organization.

ABSTRACT: Coordinated cell movements are crucial for vertebrate gastrulation and are controlled by multiple signals. Although many factors are shown to mediate non-canonical Wnt pathways to regulate cell polarity and intercalation during gastrulation, signaling molecules acting in other pathways are less investigated and the connections between various signals and cytoskeleton are not well understood. In this study, we show that the cytoplasmic tyrosine kinase Arg modulates gastrulation movements through control of actin remodeling. Arg is expressed in the dorsal mesoderm at the onset of gastrulation, and both gain- and loss-of-function of Arg disrupted axial development in Xenopus embryos. Arg controlled migration of anterior mesendoderm, influenced cell decision on individual versus collective mig

SUBMITTER: Bonacci G 

PROVIDER: S-EPMC3294122 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature