Systemic responses of preterm newborns with presumed or documented bacteraemia.

ABSTRACT:

Aim

To compare the frequency of elevated concentrations of inflammation-related proteins in the blood of infants born before the 28th week of gestation who had documented bacteraemia and those who had presumed (antibiotic-treated but culture-negative) bacteraemia to those who had neither.

Methods

The subjects of this study are the 868 infants born at 14 institutions for whom information about protein measurements on at least two of the three protocol days (days 1, 7, and 14) was available and who did not have Bell stage 3 necrotizing enterocolitis or isolated bowel perforation, which were strongly associated with bacteraemia in this sample.

Results

Newborns with presumed early (week 1) bacteraemia had elevated concentrations of only a few inflammation-related proteins

SUBMITTER: Leviton A 

PROVIDER: S-EPMC3294175 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature