GABRA2 and KIBRA genotypes predict early relapse to substance use.

ABSTRACT:

Background

Numerous single nucleotide polymorphisms (SNPs) within different genes have been associated with alcohol and drug involvement or known risk factors for involvement, such as impaired cognitive control. The ability of these SNPs to predict re-involvement, defined here as abstinence failure during treatment, has not been thoroughly tested.

Methods

We studied a small sample (n=146; 49% female) of residential substance abuse treatment program patients who had maintained 2-6 months of abstinence. They were followed for 4 months thereafter for the purpose of counting days until the first abstinence violation. The analysis used logistic and Cox regression methods to evaluate the contributions of age; sex; number of intake alcohol, drug use, and depression symptoms; and ei

SUBMITTER: Bauer LO 

PROVIDER: S-EPMC3294190 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature