How to cluster gene expression dynamics in response to environmental signals.

ABSTRACT: Organisms usually cope with change in the environment by altering the dynamic trajectory of gene expression to adjust the complement of active proteins. The identification of particular sets of genes whose expression is adaptive in response to environmental changes helps to understand the mechanistic base of gene-environment interactions essential for organismic development. We describe a computational framework for clustering the dynamics of gene expression in distinct environments through Gaussian mixture fitting to the expression data measured at a set of discrete time points. We outline a number of quantitative testable hypotheses about the patterns of dynamic gene expression in changing environments and gene-environment interactions causing developmental differentiation. The future di

SUBMITTER: Wang Y 

PROVIDER: S-EPMC3294239 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature