Point-and-click cursor control with an intracortical neural interface system by humans with tetraplegia.

ABSTRACT: We present a point-and-click intracortical neural interface system (NIS) that enables humans with tetraplegia to volitionally move a 2-D computer cursor in any desired direction on a computer screen, hold it still, and click on the area of interest. This direct brain-computer interface extracts both discrete (click) and continuous (cursor velocity) signals from a single small population of neurons in human motor cortex. A key component of this system is a multi-state probabilistic decoding algorithm that simultaneously decodes neural spiking activity of a small population of neurons and outputs either a click signal or the velocity of the cursor. The algorithm combines a linear classifier, which determines whether the user is intending to click or move the cursor, with a Kalman filter that

SUBMITTER: Kim SP 

PROVIDER: S-EPMC3294291 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature