3DSwap: curated knowledgebase of proteins involved in 3D domain swapping.

ABSTRACT: Three-dimensional domain swapping is a unique protein structural phenomenon where two or more protein chains in a protein oligomer share a common structural segment between individual chains. This phenomenon is observed in an array of protein structures in oligomeric conformation. Protein structures in swapped conformations perform diverse functional roles and are also associated with deposition diseases in humans. We have performed in-depth literature curation and structural bioinformatics analyses to develop an integrated knowledgebase of proteins involved in 3D domain swapping. The hallmark of 3D domain swapping is the presence of distinct structural segments such as the hinge and swapped regions. We have curated the literature to delineate the boundaries of these regions. In addition,

SUBMITTER: Shameer K 

PROVIDER: S-EPMC3294423 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature