Phylogenetic framework and molecular signatures for the main clades of the phylum Actinobacteria.

ABSTRACT: The phylum Actinobacteria harbors many important human pathogens and also provides one of the richest sources of natural products, including numerous antibiotics and other compounds of biotechnological interest. Thus, a reliable phylogeny of this large phylum and the means to accurately identify its different constituent groups are of much interest. Detailed phylogenetic and comparative analyses of >150 actinobacterial genomes reported here form the basis for achieving these objectives. In phylogenetic trees based upon 35 conserved proteins, most of the main groups of Actinobacteria as well as a number of their superageneric clades are resolved. We also describe large numbers of molecular markers consisting of conserved signature indels in protein sequences and whole proteins that are spec

SUBMITTER: Gao B 

PROVIDER: S-EPMC3294427 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature