Genetic structure of Plasmodium falciparum and elimination of malaria, Comoros archipelago.

ABSTRACT: The efficacy of malaria control and elimination on islands may depend on the intensity of new parasite inflow. On the Comoros archipelago, where falciparum malaria remains a major public health problem because of spread of drug resistance and insufficient malaria control, recent interventions for malaria elimination were planned on Moheli, 1 of 4 islands in the Comoros archipelago. To assess the relevance of such a local strategy, we performed a population genetics analysis by using multilocus microsatellite and resistance genotyping of Plasmodium falciparum sampled from each island of the archipelago. We found a contrasted population genetic structure explained by geographic isolation, human migration, malaria transmission, and drug selective pressure. Our findings suggest that malaria el

SUBMITTER: Rebaudet S 

PROVIDER: S-EPMC3294527 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature