Metabolomic analysis reveals that carnitines are key regulatory metabolites in phase transition of the locusts.

ABSTRACT: Phenotypic plasticity occurs prevalently and plays a vital role in adaptive evolution. However, the underlying molecular mechanisms responsible for the expression of alternate phenotypes remain unknown. Here, a density-dependent phase polyphenism of Locusta migratoria was used as the study model to identify key signaling molecules regulating the expression of phenotypic plasticity. Metabolomic analysis, using high-performance liquid chromatography and gas chromatography-mass spectrometry, showed that solitarious and gregarious locusts have distinct metabolic profiles in hemolymph. A total of 319 metabolites, many of which are involved in lipid metabolism, differed significantly in concentration between the phases. In addition, the time course of changes in the metabolic profiles of locust

SUBMITTER: Wu R 

PROVIDER: S-EPMC3295283 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature