Computerized cognitive training restores neural activity within the reality monitoring network in schizophrenia.

ABSTRACT: Schizophrenia patients suffer from severe cognitive deficits, such as impaired reality monitoring. Reality monitoring is the ability to distinguish the source of internal experiences from outside reality. During reality monitoring tasks, schizophrenia patients make errors identifying "I made it up" items, and even during accurate performance, they show abnormally low activation of the medial prefrontal cortex (mPFC), a region that supports self-referential cognition. We administered 80 hr of computerized training of cognitive processes to schizophrenia patients and found improvement in reality monitoring that correlated with increased mPFC activity. In contrast, patients in a computer games control condition did not show any behavioral or neural improvements. Notably, recovery in mPFC acti

SUBMITTER: Subramaniam K 

PROVIDER: S-EPMC3295613 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature