DNA repair in human pluripotent stem cells is distinct from that in non-pluripotent human cells.

ABSTRACT: The potential for human disease treatment using human pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells (iPSCs), also carries the risk of added genomic instability. Genomic instability is most often linked to DNA repair deficiencies, which indicates that screening/characterization of possible repair deficiencies in pluripotent human stem cells should be a necessary step prior to their clinical and research use. In this study, a comparison of DNA repair pathways in pluripotent cells, as compared to those in non-pluripotent cells, demonstrated that DNA repair capacities of pluripotent cell lines were more heterogeneous than those of differentiated lines examined and were generally greater. Although pluripotent cells had high DNA repair capacities for n

SUBMITTER: Luo LZ 

PROVIDER: S-EPMC3295811 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature