Endothelial dysfunction in children without hypertension: potential contributions of obesity and obstructive sleep apnea.

ABSTRACT:

Background

Endothelial dysfunction can develop in the context of both obesity and obstructive sleep apnea (OSA) in children. However, the potential interactions between OSA and obesity have not been defined.

Methods

Children who were prepubertal and nonhypertensive were recruited. Endothelial function was assessed in a morning fasted state, using a modified hyperemic test involving cuff-induced occlusion of the radial and ulnar arteries, and blood was drawn for assessment of myeloid-related protein 8/14 (MRP8/14) levels using a commercial enzyme-linked immunosorbent assay. Overnight polysomnography defined the presence of OSA or absence of OSA (NOSA) in subjects investigated for sleep-disordered breathing. Anthropometric measurements were performed to assign subjects to obes

SUBMITTER: Bhattacharjee R 

PROVIDER: S-EPMC3296460 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature