Development of a cDNA microarray for the measurement of gene expression in the sheep scab mite Psoroptes ovis.

ABSTRACT:

Background

Sheep scab is caused by the ectoparasitic mite Psoroptes ovis which initiates a profound cutaneous inflammatory response, leading to the development of the skin lesions which are characteristic of the disease. Existing control strategies rely upon injectable endectocides and acaricidal dips but concerns over residues, eco-toxicity and the development of acaricide resistance limit the sustainability of this approach. In order to identify alternative means of disease control, a deeper understanding of both the parasite and its interaction with the host are required.

Methods

Herein we describe the development and utilisation of an annotated P. ovis cDNA microarray containing 3,456 elements for the measurement of gene expression in this economically important ectopara

SUBMITTER: Burgess ST 

PROVIDER: S-EPMC3296576 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature