Accelerated wound healing phenotype in Interleukin 12/23 deficient mice.

ABSTRACT:

Background

The concept that a strong inflammatory response involving the full complement of cytokines and other mediators is critical for unimpaired healing has been challenged by wound healing studies using transgenic and knockout (KO) mice. The present study explored the effect of abrogation of the p40 subunit, which is shared by the pro-inflammatory cytokines interleukin (IL)-12 and IL-23, on wound closure of excisional oral mucosal wounds.

Methods

Double IL-12 and IL-23 KO mice and C57BL ⁄ 6J wildtype mice were wounded on the dorsal surface of the tongue using a 2 mm biopsy punch. The degree of epithelialization was examined histologically. At specific timepoints wounds were examined for cellular and molecular markers for inflammation and angiogenesis using 1) immunohist

SUBMITTER: Matias MA 

PROVIDER: S-EPMC3296624 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature