Transcription analysis on response of porcine alveolar macrophages to Haemophilus parasuis.

ABSTRACT:

Background

Haemophilus parasuis (H. parasuis) is the etiological agent of Glässer's disease in pigs. Currently, the molecular basis of this infection is largely unknown. The innate immune response is the first line of defense against the infectious disease. Systematical analysis on host innate immune response to the infection is important for understanding the pathogenesis of the infectious microorganisms.

Results

A total of 428 differentially expressed (DE) genes were identified in the porcine alveolar macrophages (PAMs) 6 days after H. parasuis infection. These genes were principally related to inflammatory response, immune response, microtubule polymerization, regulation of transcript and signal transduction. Through the pathway analysis, the significant pathways mainly c

SUBMITTER: Wang Y 

PROVIDER: S-EPMC3296652 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature