Parvovirus b19 DNA CpG dinucleotide methylation and epigenetic regulation of viral expression.

ABSTRACT: CpG DNA methylation is one of the main epigenetic modifications playing a role in the control of gene expression. For DNA viruses whose genome has the ability to integrate in the host genome or to maintain as a latent episome, a correlation has been found between the extent of DNA methylation and viral quiescence. No information is available for Parvovirus B19, a human pathogenic virus, which is capable of both lytic and persistent infections. Within Parvovirus B19 genome, the inverted terminal regions display all the characteristic signatures of a genomic CpG island; therefore we hypothesised a role of CpG dinucleotide methylation in the regulation of viral genome expression.The analysis of CpG dinucleotide methylation of Parvovirus B19 DNA was carried out by an aptly designed quantitativ

SUBMITTER: Bonvicini F 

PROVIDER: S-EPMC3296687 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature