Evolution of JAK-STAT pathway components: mechanisms and role in immune system development.

ABSTRACT:

Background

Lying downstream of a myriad of cytokine receptors, the Janus kinase (JAK)-Signal transducer and activator of transcription (STAT) pathway is pivotal for the development and function of the immune system, with additional important roles in other biological systems. To gain further insight into immune system evolution, we have performed a comprehensive bioinformatic analysis of the JAK-STAT pathway components, including the key negative regulators of this pathway, the SH2-domain containing tyrosine phosphatase (SHP), Protein inhibitors against Stats (PIAS), and Suppressor of cytokine signaling (SOCS) proteins across a diverse range of organisms.

Results

Our analysis has demonstrated significant expansion of JAK-STAT pathway components co-incident with the emergence

SUBMITTER: Liongue C 

PROVIDER: S-EPMC3296744 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature