Paraneoplastic thrombocytosis in ovarian cancer.

ABSTRACT:

Background

The mechanisms of paraneoplastic thrombocytosis in ovarian cancer and the role that platelets play in abetting cancer growth are unclear.

Methods

We analyzed clinical data on 619 patients with epithelial ovarian cancer to test associations between platelet counts and disease outcome. Human samples and mouse models of epithelial ovarian cancer were used to explore the underlying mechanisms of paraneoplastic thrombocytosis. The effects of platelets on tumor growth and angiogenesis were ascertained.

Results

Thrombocytosis was significantly associated with advanced disease and shortened survival. Plasma levels of thrombopoietin and interleukin-6 were significantly elevated in patients who had thrombocytosis as compared with those who did not. In mouse models, i

SUBMITTER: Stone RL 

PROVIDER: S-EPMC3296780 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature