Four eremophilane sesquiterpenes from the mangrove endophytic fungus Xylaria sp. BL321.

ABSTRACT: Three new eremophilane sesquiterpenes (1-3) were isolated from the mangrove endophytic fungus Xylaria sp. BL321 together with 07H239-A (4), a known analogue of the new compounds. The structures of these compounds were elucidated by analysis of their MS, 1D and 2D NMR spectroscopic data. Compound 4 showed activation activity on α-glucosidase at 0.15 μM (146%), and then, 4 gradually produced inhibitory activity on α-glucosidase with increasing concentration, and the IC₅₀ value is 6.54 μM.

SUBMITTER: Song Y 

PROVIDER: S-EPMC3297001 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature