Differential association between the norepinephrine transporter gene and ADHD: role of sex and subtype.

ABSTRACT:

Background

Pharmacologic and animal studies have strongly implicated the norepinephrine transporter (NET) in the pathophysiology of attention-deficit/hyperactivity disorder (ADHD). We conducted a family-based study, with stratification based on sex and subtype, to test the association between 30 tag single-nucleotide polymorphisms (SNPs) within the gene encoding NET (SLC6A2) and ADHD.

Methods

Family-based association tests were conducted with the categorical diagnosis of ADHD, as well as quantitative phenotypes of clinical relevance (Conners Global Index for Teachers and Parents, and Child Behavior Checklist measures). Sliding window haplotype analysis was conducted with screening based on conditional power using PBAT.

Results

A previously reported association with rs

SUBMITTER: Sengupta SM 

PROVIDER: S-EPMC3297073 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature