Diesel exhaust exposure and nasal response to attenuated influenza in normal and allergic volunteers.

ABSTRACT:

Rationale

Diesel exhaust enhances allergic inflammation, and pollutants are associated with heightened susceptibility to viral respiratory infections. The effects of combined diesel and virus exposure in humans are unknown.

Objectives

Test whether acute exposure to diesel modifies inflammatory responses to influenza virus in normal humans and those with allergies.

Methods

We conducted a double-blind, randomized, placebo-controlled study of nasal responses to live attenuated influenza virus in normal volunteers and those with allergic rhinitis exposed to diesel (100 μg/m(3)) or clean air for 2 hours, followed by standard dose of virus and serial nasal lavages. Endpoints were inflammatory mediators (ELISA) and virus quantity (quantitative reverse-transcriptase polymeras

SUBMITTER: Noah TL 

PROVIDER: S-EPMC3297091 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature