Metabolic syndrome biomarkers predict lung function impairment: a nested case-control study.

ABSTRACT:

Rationale

Cross-sectional studies demonstrate an association between metabolic syndrome and impaired lung function.

Objectives

To define if metabolic syndrome biomarkers are risk factors for loss of lung function after irritant exposure.

Methods

A nested case-control study of Fire Department of New York personnel with normal pre-September 11th FEV(1) and who presented for subspecialty pulmonary evaluation before March 10, 2008. We correlated metabolic syndrome biomarkers obtained within 6 months of World Trade Center dust exposure with subsequent FEV(1). FEV(1) at subspecialty pulmonary evaluation within 6.5 years defined disease status; cases had FEV(1) less than lower limit of normal, whereas control subjects had FEV(1) greater than or equal to lower limit of normal

SUBMITTER: Naveed B 

PROVIDER: S-EPMC3297095 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature