Evidence for a causal relationship between allergic sensitization and rhinovirus wheezing in early life.

ABSTRACT:

Rationale

Aeroallergen sensitization and virus-induced wheezing are risk factors for asthma development during early childhood, but the temporal developmental sequence between them is incompletely understood.

Objective

To define the developmental relationship between aeroallergen sensitization and virus-induced wheezing.

Methods

A total of 285 children at high risk for allergic disease and asthma were followed prospectively from birth. The timing and etiology of viral respiratory wheezing illnesses were determined, and aeroallergen sensitization was assessed annually for the first 6 years of life. The relationships between these events were assessed using a longitudinal multistate Markov model.

Measurements and main results

Children who were sensitized to aeroa

SUBMITTER: Jackson DJ 

PROVIDER: S-EPMC3297109 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature