Pro-/anti-inflammatory cytokine gene polymorphisms and chronic kidney disease: a cross-sectional study.

ABSTRACT:

Background

The aim of this study was to explore the associations between common potential functional promoter polymorphisms in pro-/anti-inflammatory cytokine genes and kidney function/chronic kidney disease (CKD) prevalence in a large Japanese population.

Methods

A total of 3,323 subjects aged 35-69 were genotyped for all 10 single nucleotide polymorphisms (SNPs) in the promoter regions of candidate genes with minor allele frequencies of > 0.100 in Japanese populations. The estimated glomerular filtration rate (eGFR) and CKD prevalence (eGFR < 60 ml/min/1.73 m2) of the subjects were compared among the genotypes.

Results

A higher eGFR and lower prevalence of CKD were observed for the homozygous variants of IL4 -33CC (high IL-4 [anti-inflammatory cytokine]-producing ge

SUBMITTER: Okada R 

PROVIDER: S-EPMC3297507 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature