Development of a panel of genome-wide ancestry informative markers to study admixture throughout the Americas.

ABSTRACT: Most individuals throughout the Americas are admixed descendants of Native American, European, and African ancestors. Complex historical factors have resulted in varying proportions of ancestral contributions between individuals within and among ethnic groups. We developed a panel of 446 ancestry informative markers (AIMs) optimized to estimate ancestral proportions in individuals and populations throughout Latin America. We used genome-wide data from 953 individuals from diverse African, European, and Native American populations to select AIMs optimized for each of the three main continental populations that form the basis of modern Latin American populations. We selected markers on the basis of locus-specific branch length to be informative, well distributed throughout the genome, capabl

SUBMITTER: Galanter JM 

PROVIDER: S-EPMC3297575 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature