Combinatorial complexity and compositional drift in protein interaction networks.

ABSTRACT: The assembly of molecular machines and transient signaling complexes does not typically occur under circumstances in which the appropriate proteins are isolated from all others present in the cell. Rather, assembly must proceed in the context of large-scale protein-protein interaction (PPI) networks that are characterized both by conflict and combinatorial complexity. Conflict refers to the fact that protein interfaces can often bind many different partners in a mutually exclusive way, while combinatorial complexity refers to the explosion in the number of distinct complexes that can be formed by a network of binding possibilities. Using computational models, we explore the consequences of these characteristics for the global dynamics of a PPI network based on highly curated yeast two-hybr

SUBMITTER: Deeds EJ 

PROVIDER: S-EPMC3297590 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature