Common variation in Nemo-like kinase is associated with risk of ovarian cancer.

ABSTRACT:

Background

Overexpression of mitotic kinases has been associated with prognosis, histologic grade, and clinical stage in ovarian cancer, but the relationship between inherited variation in these genes and ovarian cancer risk has not been well defined.

Methods

We measured associations between 397 single nucleotide polymorphisms (SNPs) from 67 mitotic kinases and invasive epithelial ovarian cancer risk in two case-control studies (n = 671 cases; n = 939 controls). Thirty-six candidate SNPs (P < 0.05) were assessed in a replication analysis consisting of three additional studies (n = 1,094 cases; n = 829 controls).

Results

In initial analysis, thirty-six SNPs were suggestive of association with risk of serous ovarian cancer, all subtypes of ovarian cancer, or both (P < 0

SUBMITTER: Stevens KN 

PROVIDER: S-EPMC3297683 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature