Gene set analysis of survival following ovarian cancer implicates macrolide binding and intracellular signaling genes.

ABSTRACT:

Background

Genome-wide association studies (GWAS) for epithelial ovarian cancer (EOC), the most lethal gynecologic malignancy, have identified novel susceptibility loci. GWAS for survival after EOC have had more limited success. The association of each single-nucleotide polymorphism (SNP) individually may not be well suited to detect small effects of multiple SNPs, such as those operating within the same biologic pathway. Gene set analysis (GSA) overcomes this limitation by assessing overall evidence for association of a phenotype with all measured variation in a set of genes.

Methods

To determine gene sets associated with EOC overall survival, we conducted GSA using data from two large GWAS (N cases = 2,813, N deaths = 1,116), with a novel Principal Component-Gamma GSA meth

SUBMITTER: Fridley BL 

PROVIDER: S-EPMC3297690 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature