A three-dimensional simulation model of cardiomyocyte integrating excitation-contraction coupling and metabolism.

ABSTRACT: Recent studies have revealed that Ca(2+) not only regulates the contraction of cardiomyocytes, but can also function as a signaling agent to stimulate ATP production by the mitochondria. However, the spatiotemporal resolution of current experimental techniques limits our investigative capacity to understand this phenomenon. Here, we created a detailed three-dimensional (3D) cardiomyocyte model to study the subcellular regulatory mechanisms of myocardial energetics. The 3D cardiomyocyte model was based on the finite-element method, with detailed subcellular structures reproduced, and it included all elementary processes involved in cardiomyocyte electrophysiology, contraction, and ATP metabolism localized to specific loci. The simulation results were found to be reproducible and consistent

SUBMITTER: Hatano A 

PROVIDER: S-EPMC3297787 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature