Decreased regional cortical thickness and thinning rate are associated with inattention symptoms in healthy children.

ABSTRACT:

Objective

Children with attention-deficit/hyperactivity disorder (ADHD) have delayed cortical maturation, evidenced by regionally specific slower cortical thinning. However, the relationship between cortical maturation and attention capacities in typically developing children is unknown. This study examines cortical thickness correlates of inattention symptoms in a large sample of healthy children.

Method

Data from 357 healthy subjects (6.0-18.4 years of age) were obtained from the NIH MRI Study of Normal Brain Development. In cross-sectional analysis (first visit, n = 257), Child Behavior Checklist Attention Problems (AP) scores were linearly regressed against cortical thickness, controlling for age, gender, total brain volume, and site. For longitudinal data (up to three v

SUBMITTER: Ducharme S 

PROVIDER: S-EPMC3297982 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature