Intramolecular Pd(II)-catalyzed aerobic oxidative amination of alkenes: synthesis of six-membered N-heterocycles.

ABSTRACT: Use of a base-free Pd(DMSO)(2)(TFA)(2) catalyst system enables the synthesis of six-membered nitrogen heterocycles via a Wacker-type aerobic oxidative cyclization of alkenes bearing tethered sulfonamides. Various heterocycles, including morpholines, piperidines, piperazines, and piperazinones, are accessible by this method.

SUBMITTER: Lu Z 

PROVIDER: S-EPMC3298079 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature