Identification of the herboxidiene biosynthetic gene cluster in Streptomyces chromofuscus ATCC 49982.

ABSTRACT: The 53-kb biosynthetic gene cluster for the novel anticholesterol natural product herboxidiene was identified in Streptomyces chromofuscus ATCC 49982 by genome sequencing and gene inactivation. In addition to herboxidiene, a biosynthetic intermediate, 18-deoxy-herboxidiene, was also isolated from the fermentation broth of S. chromofuscus ATCC 49982 as a minor metabolite.

SUBMITTER: Shao L 

PROVIDER: S-EPMC3298124 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature