Genetically determined dosage of follicle-stimulating hormone (FSH) affects male reproductive parameters.

ABSTRACT:

Context

The detailed role of FSH in contributing to male testicular function and fertility has been debated. We have previously identified the association between the T-allele of the FSHB promoter polymorphism (rs10835638; G/T, -211 bp from the mRNA start) and significantly reduced male serum FSH.

Objective

In the current study, the T-allele carriers of the FSHB -211 G/T single nucleotide polymorphism represented a natural model for documenting downstream phenotypic consequences of insufficient FSH action.

Design and subjects

We genotyped rs10835638 in the population-based Baltic cohort of young men (n = 1054; GG carriers, n = 796; GT carriers, n = 244; TT carriers, n = 14) recruited by Andrology Centres in Tartu, Estonia; Riga, Latvia; and Kaunas, Lithuania. Marker-t

SUBMITTER: Grigorova M 

PROVIDER: S-EPMC3298437 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature