Characterization of Salvia miltiorrhiza ethanol extract as an anti-osteoporotic agent.

ABSTRACT:

Background

Salvia miltiorrhiza (SM) has long been used as a traditional oriental medicine for cardiovascular disease. Accumulating evidence also indicates that SM has anti-osteoporotic effects. This study was conducted to examine the SM-induced anti-osteoporotic effect and its possible mechanisms with various doses of SM.

Methods

We studied Sprague-Dawley female rats aged 12 weeks, divided into six groups: sham-operated control (SHAM), OVX rats supplemented with SM (1, 3, 10 and 30 mg/kg) orally for 8 weeks. At the end of the experiment, blood samples were collected and biochemistry analysis was performed. Specimens from both tibia and liver were processed for light microscopic examination. DEXA and μ-CT analyses of the tibia were also performed.

Results

SM treatment

SUBMITTER: Cui Y 

PROVIDER: S-EPMC3298536 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature