Association of Fc receptor-like 5 (FCRL5) with Graves' disease is secondary to the effect of FCRL3.

ABSTRACT:

Objective

The Fc receptor-like 3 (FCRL3) molecule, involved in controlling B-cell signalling, may contribute to the autoimmune disease process. Recently, a genome-wide screen detected association of neighbouring gene FCRL5 with Graves' disease (GD). To determine whether FCRL5 represents a further independent B-cell signalling GD susceptibility loci, we screened 12 tag SNPs, capturing all known common variation within FCRL5, in 5192 UK Caucasian GD index cases and controls.

Design

A case-control association study investigating twelve tag SNPs within FCRL5 which captured the majority of known common variation within this gene region.

Patients

A data set comprising 2504 UK Caucasian patients with GD and 2688 geographically matched controls taken from the 1958 British Bir

SUBMITTER: Simmonds MJ 

PROVIDER: S-EPMC3299549 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature