Dietary moderately oxidized oil activates the Nrf2 signaling pathway in the liver of pigs.

ABSTRACT:

Background

Previous studies have shown that administration of oxidized oils increases gene expression and activities of various enzymes involved in xenobiotic metabolism and stress response in the liver of rats and guinea pigs. As these genes are controlled by nuclear factor erythroid-derived 2-like 2 (Nrf2), we investigated the hypothesis that feeding of oxidized fats causes an activation of that transcription factor in the liver which in turn activates the expression of antioxidant, cytoprotective and detoxifying genes.

Methods

Twenty four crossbred pigs were allocated to two groups of 12 pigs each and fed nutritionally adequate diets with either fresh rapeseed oil (fresh fat group) or oxidized rapeseed oil prepared by heating at a temperature of 175°C for 72 h (oxidized f

SUBMITTER: Varady J 

PROVIDER: S-EPMC3299602 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature