Association of LMP/TAP gene polymorphisms with tuberculosis susceptibility in Li population in China.

ABSTRACT:

Background

Tuberculosis (TB) is a contagious disease affected by multiple genetic and environmental factors. Several association studies have suggested that cellular immune response is vital for controlling and preventing of tuberculosis infection. Low molecular weight polypeptides (LMPs) and transporters with antigen processing (TAPs) are the main molecules in the processing and presentation pathway for intracellular antigens. This study was performed to elucidate whether these antigen-processing genes (LMP/TAP) polymorphisms could be associated with the risk of tuberculosis infection in China.

Methodology/principal findings

We recruited 205 active pulmonary tuberculosis patients and 217 normal controls from Li population for this study. Four polymorphisms of LMP/TAP genes

SUBMITTER: Wang D 

PROVIDER: S-EPMC3299725 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature